Recent Publications

  • Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets. Ahmad F, Murata T, Simizu K, Degerman E, Maurice DH, Manganiello V. Oral Diseases 2014 21:25-50.
  • Advances in targeting cyclic nucleotide phosphodiesterases. Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganie VC. Nature Reviews Drug Discovery 2014 13:290-314.
  • Cyclic nucleotide phosphodiesterases (PDEs): coincidence detectors acting to spatially and temporally integrate cyclic nucleotide and non-cyclic nucleotide signals. Maurice DH, Wilson LS, Rampersad SN, Hubert F, Truong T, Kaczmarek M, Brzezinska P, Freitag SI, Umana MB, Wudwud A. Biochem Soc Transact 2014 42:250-6.
  • Cyclic nucleotide-based therapeutics for chronic obstructive pulmonary disease. Giembycz MA, Maurice DH. Curr Opin Pharmacol. 2014 16:89-107.
  • PDE8A runs interference to limit PKA inhibition of Raf-1. Maurice DH.  Proc Natl Acad Sci U S A. 2013 110:6248-9. 
  • Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease. Lee LC, Maurice DH, Baillie GS.  Future Med Chem. 2013 5:451-64.
  • Potential therapeutic applications of phosphodiesterase inhibition in prostate cancer. Hamilton TK, Hu N, Kolomitro K, Bell EN, Maurice DH, Graham CH, Siemens DR. World J Urol. 2013 31:325-30.
  • Subcellular signaling in the endothelium: cyclic nucleotides take their place. Maurice DH.  Curr Opin Pharmacol. 2011 11:656-64.
  • Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. Circ Res. 2011 109:1024-30.
  • A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells. Wilson LS, Baillie GS, Pritchard LM, Umana B, Terrin A, Zaccolo M, Houslay MD, Maurice DH. J Biol Chem. 2011 286:16285-96.
  • Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability. Rampersad SN, Ovens JD, Huston E, Umana MB, Wilson LS, Netherton SJ, Lynch MJ, Baillie GS, Houslay MD, Maurice DH. J Biol Chem. 2010 285:33614-22.
  • Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes. Raymond DR, Carter RL, Ward CA, Maurice DH. Am J Physiol Heart Circ Physiol. 2009 296:H263-71.