PDE4 Publications

  • Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability. Rampersad SN, Ovens JD, Huston E, Umana MB, Wilson LS, Netherton SJ, Lynch MJ, Baillie GS, Houslay MD, Maurice DH. J Biol Chem. 2010 Oct 29;285(44):33614-22.
  • Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes. Raymond DR, Carter RL, Ward CA, Maurice DH. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H263-71.
  • Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion. Raymond DR, Wilson LS, Carter RL, Maurice DH. Cell Signal. 2007 Dec;19(12):2507-18.
  • Both protein kinase A and exchange protein activated by cAMP coordinate adhesion of human vascular endothelial cells. Netherton SJ, Sutton JA, Wilson LS, Carter RL, Maurice DH. Circ Res. 2007 Oct 12;101(8):768-76.
  • PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Kerfant BG, Zhao D, Lorenzen-Schmidt I, Wilson LS, Cai S, Chen SR, Maurice DH, Backx PH. Circ Res. 2007 Aug 17;101(4):400-8
  • Vascular smooth muscle cell phenotype-dependent phosphodiesterase 4D short form expression: role of differential histone acetylation on cAMP-regulated function. Tilley DG, Maurice DH. Mol Pharmacol. 2005 Sep;68(3):596-605.
  • Vascular endothelial cell cyclic nucleotide phosphodiesterases and regulated cell migration: implications in angiogenesis. Netherton SJ, Maurice DH. Mol Pharmacol. 2005 Jan;67(1):263-72.
  • Vascular smooth muscle cell phosphodiesterase (PDE) 3 and PDE4 activities and levels are regulated by cyclic AMP in vivo. Tilley DG, Maurice DH. Mol Pharmacol. 2002 Sep;62(3):497-506.
  • Expression of phosphodiesterase 4D (PDE4D) is regulated by both the cyclic AMP-dependent protein kinase and mitogen-activated protein kinase signaling pathways. A potential mechanism allowing for the coordinated regulation of PDE4D activity and expression in cells. Liu H, Palmer D, Jimmo SL, Tilley DG, Dunkerley HA, Pang SC, Maurice DH. J Biol Chem. 2000 Aug 25;275(34):26615-24.
  • Phosphorylation-mediated activation and translocation of the cyclic AMP-specific phosphodiesterase PDE4D3 by cyclic AMP-dependent protein kinase and mitogen-activated protein kinases. A potential mechanism allowing for the coordinated regulation of PDE4D activity and targeting. Liu H, Maurice DH. J Biol Chem. 1999 Apr 9;274(15):10557-65.
  • Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors. Palmer D, Tsoi K, Maurice DH. Circ Res. 1998 May 4;82(8):852-61.
  • Cyclic AMP-mediated regulation of vascular smooth muscle cell cyclic AMP phosphodiesterase activity. Rose RJ, Liu H, Palmer D, Maurice DH. Br J Pharmacol. 1997 Sep;122(2):233-40.